期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 14, 页码 -出版社
MDPI
DOI: 10.3390/ijms22147519
关键词
acupuncture; intracranial self-stimulation; rats; medial forebrain bundle; cocaine; brain reward function
资金
- Ministry of Food and Drug Safety [20182MFDS422]
- National Research Foundation of Korea (NRF) grant from the Korea government MSIT [2018R1A5A2025272, 2019R1I1A1A01052581]
- National Research Foundation of Korea [2019R1I1A1A01052581] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Acupuncture at HT7 acupoint can regulate the brain reward function of rats and elevate ICSS thresholds. However, it does not affect the threshold-lowering effects produced by cocaine, indicating that it only effectively regulates the ICSS thresholds in drug-naive rats.
Acupuncture affects the central nervous system via the regulation of neurotransmitter transmission. We previously showed that Shemen (HT7) acupoint stimulation decreased cocaine-induced dopamine release in the nucleus accumbens. Here, we used the intracranial self-stimulation (ICSS) paradigm to evaluate whether HT stimulation regulates the brain reward function of rats. We found that HT stimulation triggered a rightward shift of the frequency-rate curve and elevated the ICSS thresholds. However, HT7 stimulation did not affect the threshold-lowering effects produced by cocaine. These results indicate that HT7 points only effectively regulates the ICSS thresholds of the medial forebrain bundle in drug-naive rats.
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