期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/ijms22158153
关键词
hypoxia; HIF-1 alpha; RAGE; S100 proteins; HMGB1; cancer
资金
- College of Health Professions at NDSU
- NIH [U54GM128729]
Hypoxia, characterized by inadequate oxygen supply to tissues, is common in solid tumors. Cellular response to hypoxic conditions is mediated by activating HIFs, which control the expression of many target genes. Recent studies suggest that RAGE signaling plays a crucial role in tumor biology under hypoxic conditions.
Hypoxia is characterized by an inadequate supply of oxygen to tissues, and hypoxic regions are commonly found in solid tumors. The cellular response to hypoxic conditions is mediated through the activation of hypoxia-inducible factors (HIFs) that control the expression of a large number of target genes. Recent studies have shown that the receptor for advanced glycation end products (RAGE) participates in hypoxia-dependent cellular adaptation. We review recent evidence on the role of RAGE signaling in tumor biology under hypoxic conditions.
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