Copper, Iron, Selenium and Lipo-Glycemic Dysmetabolism in Alzheimer's Disease

The aim of the present review is to discuss traditional hypotheses on the etiopathogenesis of Alzheimer's disease (AD), as well as the role of metabolic-syndrome-related mechanisms in AD development with a special focus on advanced glycation end-products (AGEs) and their role in metal-induced neurodegeneration in AD. Persistent hyperglycemia along with oxidative stress results in increased protein glycation and formation of AGEs. The latter were shown to possess a wide spectrum of neurotoxic effects including increased A beta generation and aggregation. In addition, AGE binding to receptor for AGE (RAGE) induces a variety of pathways contributing to neuroinflammation. The existing data also demonstrate that AGE toxicity seems to mediate the involvement of copper (Cu) and potentially other metals in AD pathogenesis. Specifically, Cu promotes AGE formation, AGE-A beta cross-linking and up-regulation of RAGE expression. Moreover, A beta glycation was shown to increase prooxidant effects of Cu through Fenton chemistry. Given the role of AGE and RAGE, as well as metal toxicity in AD pathogenesis, it is proposed that metal chelation and/or incretins may slow down oxidative damage. In addition, selenium (Se) compounds seem to attenuate the intracellular toxicity of the deranged tau and A beta, as well as inhibiting AGE accumulation and metal-induced neurotoxicity.

Automated summary

This review discusses traditional hypotheses on the etiopathogenesis of Alzheimer's disease and the role of metabolic-syndrome-related mechanisms in disease development, with a focus on advanced glycation end-products (AGEs) and their involvement in metal-induced neurodegeneration. The review highlights the neurotoxic effects of AGEs, their binding to RAGE, and the potential role of metals like copper in AD pathogenesis.