4.7 Article

Deciphering the Potential Neuroprotective Effects of Luteolin against Aβ1-42-Induced Alzheimer's Disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Quinpirole-Mediated Regulation of Dopamine D2 Receptors Inhibits Glial Cell-Induced Neuroinflammation in Cortex and Striatum after Brain Injury

Sayed Ibrar Alam et al.

Summary: This study demonstrated that quinpirole significantly reduced glial cell-induced neuroinflammation in a TBI model through regulation of the D2R/Akt/GSK3β signaling pathway. Quinpirole treatment also attenuated neuronal apoptosis, synaptic dysfunction, and promoted recovery of lesion volume in the TBI mouse model.

BIOMEDICINES (2021)

Review Biochemistry & Molecular Biology

Neuroinflammation in Alzheimer's disease and beneficial action of luteolin

Alejandro Delgado et al.

Summary: Alzheimer's disease, the most common form of dementia globally, is expected to continue to rise in prevalence in the coming decades. Despite historical research on the amyloid cascade hypothesis, recent literature emphasizes the key role of neuroinflammation, particularly microglial activation, in the pathogenesis of AD. In addition, flavonoids like luteolin in olive pomace oil combined with hydroxytyrosol show promise as a prophylactic treatment due to their beneficial effects.

BIOFACTORS (2021)

Review Cell Biology

Pathology, Risk Factors, and Oxidative Damage Related to Type 2 Diabetes-Mediated Alzheimer's Disease and the Rescuing Effects of the Potent Antioxidant Anthocyanin

Muhammad Sohail Khan et al.

Summary: The pathology and neurodegeneration in type 2 diabetes-mediated Alzheimer's disease have common features such as brain atrophy, reduced cerebral glucose metabolism, and insulin resistance. Type 2 diabetes phenotypes like glucose dyshomeostasis and insulin resistance contribute to the progression of Alzheimer's disease pathology through mechanisms like amyloid-beta accumulation and overall neuroinflammation. Additionally, oxidative stress, mitochondrial dysfunction, and advanced glycation end products may link diabetes and Alzheimer's disease.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Pharmacology & Pharmacy

Fisetin Rescues the Mice Brains Against D-Galactose-Induced Oxidative Stress, Neuroinflammation and Memory Impairment

Sareer Ahmad et al.

Summary: In this study, Fisetin was found to protect against d-galactose-induced oxidative stress, neuroinflammation, and memory impairment in mice by regulating antioxidant mechanisms, inhibiting inflammatory pathways, and preventing ROS accumulation. This suggests that Fisetin may be beneficial in addressing age-related neurological disorders.

FRONTIERS IN PHARMACOLOGY (2021)

Article Cell Biology

Oral Administration of Gintonin Protects the Brains of Mice against Aβ-Induced Alzheimer Disease Pathology: Antioxidant and Anti-Inflammatory Effects

Muhammad Ikram et al.

Summary: The results of the study show that gintonin reduced elevated oxidative stress by improving the expression of NRF-2 and HO-1, thereby reducing the production of reactive oxygen species (ROS) and lipid peroxidation (LPO). Additionally, gintonin significantly inhibited the activation of microglial cells and inflammatory mediators in the brains of A beta-injected mice. Moreover, treatment with gintonin improved synaptic and memory functions in the brains of A beta-injected mice.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Neurosciences

Antioxidative and Anti-inflammatory Effects of Kojic Acid in Aβ-Induced Mouse Model of Alzheimer's Disease

Amjad Khan et al.

Summary: This study demonstrated the neuroprotective effects of kojic acid in an AD mouse model, reversing AD pathology and improving memory function. Kojic acid could serve as a potential novel drug strategy for treating AD-related neurodegenerative conditions.

MOLECULAR NEUROBIOLOGY (2021)

Article Geriatrics & Gerontology

Cadmium, an Environmental Contaminant, Exacerbates Alzheimer's Pathology in the Aged Mice's Brain

Tahir Ali et al.

Summary: The study found that chronic exposure to cadmium may exacerbate memory and synaptic deficits in mice, leading to oxidative stress and the development of oxidative stress-related Alzheimer's disease (AD) pathology. This suggests the need to address the regulation of oxidative stress/ROS and the associated amyloid beta pathology.

FRONTIERS IN AGING NEUROSCIENCE (2021)

Editorial Material Neurosciences

Microglia and Reactive Oxygen Species Are Required for Behavioral Susceptibility to Chronic Social Defeat Stress

Christopher A. Guevara et al.

JOURNAL OF NEUROSCIENCE (2020)

Review Clinical Neurology

A Close Look at BACE1 Inhibitors for Alzheimer's Disease Treatment

Brati Das et al.

CNS DRUGS (2019)

Article Multidisciplinary Sciences

Alzheimer's disease: A clinical perspective and future nonhuman primate research opportunities

Rafi U. Haque et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Cell Biology

Microglia in Alzheimer's disease

David V. Hansen et al.

JOURNAL OF CELL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Oxidative stress and the amyloid beta peptide in Alzheimer's disease

C. Cheignon et al.

REDOX BIOLOGY (2018)

Review Neurosciences

Microglia in neurodegeneration

Suzanne Hickman et al.

NATURE NEUROSCIENCE (2018)

Review Geriatrics & Gerontology

Luteolin as a potential preventive and therapeutic candidate for Alzheimer's disease

Youngjoo Kwon

EXPERIMENTAL GERONTOLOGY (2017)

Article Multidisciplinary Sciences

Vanillic acid attenuates A beta(1-42)-induced oxidative stress and cognitive impairment in mice

Faiz Ul Amin et al.

SCIENTIFIC REPORTS (2017)

Review Clinical Neurology

Targeting Neuroinflammation to Treat Alzheimer's Disease

A. Ardura-Fabregat et al.

CNS DRUGS (2017)

Article Integrative & Complementary Medicine

Paeoniflorin and Albiflorin Attenuate Neuropathic Pain via MAPK Pathway in Chronic Constriction Injury Rats

Jianyu Zhou et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2016)

Article Biochemistry & Molecular Biology

Neuroinflammation: the devil is in the details

Damon J. DiSabato et al.

JOURNAL OF NEUROCHEMISTRY (2016)

Review Neurosciences

STARGAZING: MONITORING SUBCELLULAR DYNAMICS OF BRAIN ASTROCYTES

J. Benjamin Kacerovsky et al.

NEUROSCIENCE (2016)

Review Pharmacology & Pharmacy

c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer's Disease

Ramon Yarza et al.

FRONTIERS IN PHARMACOLOGY (2016)

Review Medicine, General & Internal

Amyloid-Beta: A Crucial Factor in Alzheimer's Disease

Saeed Sadigh-Eteghad et al.

MEDICAL PRINCIPLES AND PRACTICE (2015)

Article Biochemistry & Molecular Biology

Luteolin Reduces Alzheimer's Disease Pathologies Induced by Traumatic Brain Injury

Darrell Sawmiller et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

Review Neurosciences

TNF-α/NF-κB Signaling in the CNS: Possible Connection to EPHB2

Paul D. Pozniak et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2014)

Review Clinical Neurology

Targeting the β secretase BACE1 for Alzheimer's disease therapy

Riqiang Yan et al.

LANCET NEUROLOGY (2014)

Review Immunology

Mitogen-activated protein kinases in innate immunity

J. Simon C. Arthur et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Review Microbiology

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

Marie Cargnello et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2011)

Review Chemistry, Medicinal

Distribution and Biological Activities of the Flavonoid Luteolin

Miguel Lopez-Lazaro

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2009)

Article Cell Biology

Cytokine-induced β-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-XL

C. Holohan et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2008)

Article Clinical Neurology

Amyloid beta peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo

H Takuma et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2004)