期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/ijms22126413
关键词
PDAC; nuclear medicine; molecular imaging; internal vectorized radiotherapy
资金
- Government of the Principality of Monaco
- Fondation Francois Xavier Mora
- Fondation Cordon de Vie
- Fondation Flavien
- Fondation de France
- The Fondation Max et Yvonne de Foras
- La Ligue contre le Cancer-Equipe labellisee 2019
Pancreatic ductal adenocarcinoma (PDAC), which accounts for 90-95% of all pancreatic tumors, is a highly devastating disease with poor prognosis due to the lack of accurate diagnostic tests and failure of conventional therapies. Recent developments in nuclear medicine have opened up great opportunities for the management of PDAC, with the development of radiotracers and theranostics showing promise in diagnostic and therapeutic applications.
Pancreatic ductal adenocarcinoma (PDAC), accounting for 90-95% of all pancreatic tumors, is a highly devastating disease associated with poor prognosis. The lack of accurate diagnostic tests and failure of conventional therapies contribute to this pejorative issue. Over the last decade, the advent of theranostics in nuclear medicine has opened great opportunities for the diagnosis and treatment of several solid tumors. Several radiotracers dedicated to PDAC imaging or internal vectorized radiotherapy have been developed and some of them are currently under clinical consideration. The functional information provided by Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) could indeed provide an additive diagnostic value and thus help in the selection of patients for targeted therapies. Moreover, the therapeutic potential of beta(-)- and alpha-emitter-radiolabeled agents could also overcome the resistance to conventional therapies. This review summarizes the current knowledge concerning the recent developments in the nuclear medicine field for the management of PDAC patients.
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