相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise
Anders B. Klein et al.
NATURE COMMUNICATIONS (2021)
PPARs and Tumor Microenvironment: The Emerging Roles of the Metabolic Master Regulators in Tumor Stromal-Epithelial Crosstalk and Carcinogenesis
Hong Sheng Cheng et al.
CANCERS (2021)
AMPK phosphorylates PPARδ to mediate its stabilization, inhibit glucose and glutamine uptake and colon tumor growth
Jiajun Ding et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2021)
GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK
David Aguilar-Recarte et al.
CELL REPORTS (2021)
PPARs and Angiogenesis-Implications in Pathology
Nicole Wagner et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease
Anne Fougerat et al.
CELLS (2020)
Growth and differentiation factor 15 is secreted by skeletal muscle during exercise and promotes lipolysis in humans
Claire Laurens et al.
JCI INSIGHT (2020)
Growth differentiation factor 15 (GDF15): A survival protein with therapeutic potential in metabolic diseases
Seung Joon Baek et al.
PHARMACOLOGY & THERAPEUTICS (2019)
PPARδ attenuates hepatic steatosis through autophagy-mediated fatty acid oxidation
Lei Tong et al.
CELL DEATH & DISEASE (2019)
The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis
N. Jaiswal et al.
MOLECULAR METABOLISM (2019)
AMPK and PPARβ positive feedback loop regulates endurance exercise training-mediated GLUT4 expression in skeletal muscle
Jin-Ho Koh et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2019)
Non-genomic effects of nuclear receptors: insights from the anucleate platelet
Amanda J. Unsworth et al.
CARDIOVASCULAR RESEARCH (2018)
AMPK: Sensing Glucose as well as Cellular Energy Status
Sheng-Cai Lin et al.
CELL METABOLISM (2018)
AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965
Toby A. Dite et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or Therapeutic Targets?
Xavier Palomer et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2018)
The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases
Vicky W. W. Tsai et al.
CELL METABOLISM (2018)
Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology
Christoph Maack et al.
EUROPEAN HEART JOURNAL (2018)
MECHANISMS OF INSULIN ACTION AND INSULIN RESISTANCE
Max C. Petersen et al.
PHYSIOLOGICAL REVIEWS (2018)
Ligand-Dependent Interaction of PPARδ With T-Cell Protein Tyrosine Phosphatase 45 Enhances Insulin Signaling
Taesik Yoo et al.
DIABETES (2018)
A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice
Qiaoli Chen et al.
DIABETOLOGIA (2017)
Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis
Hyo Kyun Chung et al.
JOURNAL OF CELL BIOLOGY (2017)
Non - homeostatic body weight regulation through a brainstem-restricted receptor for GDF15
Jer-Yuan Hsu et al.
NATURE (2017)
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
Linda Yang et al.
NATURE MEDICINE (2017)
GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
Shannon E. Mullican et al.
NATURE MEDICINE (2017)
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL
Paul J. Emmerson et al.
NATURE MEDICINE (2017)
AMPK as a Therapeutic Target for Treating Metabolic Diseases
Emily A. Day et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2017)
PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise
Jin-Ho Koh et al.
CELL METABOLISM (2017)
Treatment of nonalcoholic fatty liver disease: role of AMPK
Brennan K. Smith et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2016)
Transcriptional control of physiological and pathological processes by the nuclear receptor PPARβ/δ
Nguan Soon Tan et al.
PROGRESS IN LIPID RESEARCH (2016)
AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs
D. Grahame Hardie et al.
TRENDS IN CELL BIOLOGY (2016)
Unraveling the Effects of PPARβ/δ on Insulin Resistance and Cardiovascular Disease
Manuel Vazquez-Carrera
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2016)
Metformin Action: Concentrations Matter
Ling He et al.
CELL METABOLISM (2015)
Nonalcoholic Fatty Liver Disease A Systematic Review
Mary E. Rinella
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)
Natural history of β-cell adaptation and failure in type 2 diabetes
Emilyn U. Alejandro et al.
MOLECULAR ASPECTS OF MEDICINE (2015)
Targeting endoplasmic reticulum stress in insulin resistance
Laia Salvado et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2015)
Insulin resistance and impaired adipogenesis
Birgit Gustafson et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2015)
Methotrexate Promotes Glucose Uptake and Lipid Oxidation in Skeletal Muscle via AMPK Activation
Sergej Pirkmajer et al.
DIABETES (2015)
Blockade of interleukin 6 signalling ameliorates systemic insulin resistance through upregulation of glucose uptake in skeletal muscle and improves hepatic steatosis in high-fat diet fed mice
Kanji Yamaguchi et al.
LIVER INTERNATIONAL (2015)
Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity
Sandra Galic et al.
BIOCHEMICAL JOURNAL (2014)
PPARβ/δ attenuates palmitate-induced endoplasmic reticulum stress and induces autophagic markers in human cardiac cells
Xavier Palomer et al.
INTERNATIONAL JOURNAL OF CARDIOLOGY (2014)
PPARδ activation attenuates hepatic steatosis in Ldlr-/- mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity
Lazar A. Bojic et al.
JOURNAL OF LIPID RESEARCH (2014)
Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle
Yang Liu et al.
BIOCHEMICAL JOURNAL (2013)
Inhibitory cross-talk between the AMPK and ERK pathways mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle
Seung-Lark Hwang et al.
BRITISH JOURNAL OF PHARMACOLOGY (2013)
AMPK, insulin resistance, and the metabolic syndrome
Neil B. Ruderman et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
The peroxisome proliferator-activated receptor (PPAR) β/δ agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells
L. Serrano-Marco et al.
DIABETOLOGIA (2012)
AMPK: a nutrient and energy sensor that maintains energy homeostasis
D. Grahame Hardie et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
PPARβ/δ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells
David Alvarez-Guardia et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2011)
AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice
Yu Li et al.
CELL METABOLISM (2011)
The PPARβ/δ Activator GW501516 Prevents the Down-Regulation of AMPK Caused by a High-Fat Diet in Liver and Amplifies the PGC-1α-Lipin 1-PPARα Pathway Leading to Increased Fatty Acid Oxidation
Emma Barroso et al.
ENDOCRINOLOGY (2011)
The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2
Zhenji Gan et al.
GENES & DEVELOPMENT (2011)
Involvement of Oxygen-regulated Protein 150 in AMP-activated Protein Kinase-mediated Alleviation of Lipid-induced Endoplasmic Reticulum Stress
Yun Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Joungmok Kim et al.
NATURE CELL BIOLOGY (2011)
Reduction of AMP-Activated Protein Kinase α2 Increases Endoplasmic Reticulum Stress and Atherosclerosis In Vivo
Yunzhou Dong et al.
CIRCULATION (2010)
Defects in Insulin Secretion and Action in the Pathogenesis of Type 2 Diabetes Mellitus
Devjit Tripathy et al.
CURRENT DIABETES REPORTS (2010)
Activation of AMP-Activated Protein Kinase Inhibits Oxidized LDL-Triggered Endoplasmic Reticulum Stress In Vivo (Publication with Expression of Concern. See vol. 72, pg. 1036, 2023)
Yunzhou Dong et al.
DIABETES (2010)
Activation of Peroxisome Proliferator-Activated Receptor-δ by GW501516 Prevents Fatty Acid-Induced Nuclear Factor-κB Activation and Insulin Resistance in Skeletal Muscle Cells
Teresa Coll et al.
ENDOCRINOLOGY (2010)
Therapeutics by Cytotoxic Metabolite Accumulation: Pemetrexed Causes ZMP Accumulation, AMPK Activation, and Mammalian Target of Rapamycin Inhibition
Alexandra C. Racanelli et al.
CANCER RESEARCH (2009)
Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes
Ralph A. DeFronzo et al.
DIABETES CARE (2009)
Autophagy regulates lipid metabolism
Rajat Singh et al.
NATURE (2009)
Inhibitory crosstalk between ERK and AMPK in the growth and proliferation of cardiac fibroblasts
Jianhai Du et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
AMPK and PPARδ Agonists are exercise mimetics
Vihang A. Narkar et al.
CELL (2008)
High-fat diets cause insulin resistance despite an increase in muscle mitochondria
Chad R. Hancock et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase
Olga Goeransson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family
Matthew J. Sanders et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Role of AMP kinase and PPARδ in the regulation of lipid and glucose metabolism in human skeletal muscle
David Kitz Kraemer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Long-term activation of adenosine monophosphate-activated protein kinase attenuates pressure-overload-induced cardiac hypertrophy
Hong-Liang Li et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2007)
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur et al.
NATURE (2006)
PGC1α expression is controlled in skeletal muscles by PPARβ, whose ablation results in fiber-type switching, obesity, and type 2 diabetes
Michael Schuler et al.
CELL METABOLISM (2006)
Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states
Yun S. Lee et al.
DIABETES (2006)
Autophagy: molecular machinery for self-eating
T Yorimitsu et al.
CELL DEATH AND DIFFERENTIATION (2005)
AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress
K Terai et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor δ
DK Krämer et al.
DIABETES (2005)
Regulation of muscle fiber type and running endurance by PPARδ
YX Wang et al.
PLOS BIOLOGY (2004)
Mechanism for fatty acid sparing effect on glucose-induced transcription - Regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase
T Kawaguchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Global and societal implications of the diabetes epidemic
P Zimmet et al.
NATURE (2001)
Characterization of growth-differentiation factor 15, a transforming growth factor β superfamily member induced following liver injury
EC Hsiao et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)