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Article
Medicine, General & Internal
Noa Dagan et al.
Summary: A study conducted in Israel on nearly 600,000 individuals showed that the BNT162b2 mRNA vaccine was effective in reducing the risk of infection, hospitalization, and severe Covid-19. The effectiveness in preventing death was 72% during the period from day 14 through day 20 after the first dose, and hospitalization was reduced by 87% for the period 7 or more days after the second dose, similar to results from a randomized trial.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Infectious Diseases
Julien Favresse et al.
Summary: The CRO-VAX HCP study investigated the early antibody response in healthcare professionals who received two doses of the BNT162b2 mRNA COVID-19 vaccine. Results showed that in previously infected individuals, a single dose of the vaccine may be sufficient, as they had higher antibody titres compared to uninfected individuals.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Infectious Diseases
Ilaria Vicenti et al.
Summary: Vaccination after infection can boost neutralizing antibody levels significantly higher than in uninfected individuals. Asymptomatic individuals with previous infection show a significant increase in neutralizing antibody titres after receiving the first vaccine dose.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
David S. Khoury et al.
Summary: The level of neutralizing antibodies is closely related to immune protection against COVID-19, playing a crucial role in protecting against detected infection and severe infection. Studies have shown that neutralizing titers will decline over time after vaccination, leading to decreased protection against SARS-CoV-2 infection.
Article
Medicine, General & Internal
Adeel A. Butt et al.
Summary: The study evaluated the short-term effectiveness of SARS-CoV-2 vaccines in preventing infection in a real-world setting. The results showed that the currently used vaccines are highly effective in preventing confirmed infection in a high-risk population, whether it is the Pfizer-BioNTech BNT-162b2 vaccine or the Moderna mRNA-1273 vaccine.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Zijun Wang et al.
Summary: Despite challenges posed by COVID-19 variants, convalescent individuals receiving mRNA vaccines exhibit robust and long-lasting immune responses against circulating SARS-CoV-2 variants, providing hope for effective control of the pandemic.
Letter
Medicine, General & Internal
Nassim Kamar et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Moriah Bergwerk et al.
Summary: Among fully vaccinated health care workers, breakthrough infections with SARS-CoV-2 were correlated with neutralizing antibody titers during the peri-infection period. Most breakthrough infections were mild or asymptomatic, although persistent symptoms did occur.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Critical Care Medicine
Yaniv Lustig et al.
Summary: The study assessed early antibody responses after Pfizer-BioNTech BNT162b2 COVID-19 vaccine in Israeli healthcare workers. Results showed that 77% of participants had positive IgG response at week 3 after the first vaccine dose, with lower responses in older and immunosuppressed individuals. Timely second dose vaccinations are particularly important for these populations to enhance antibody responses and reduce breakthrough infections.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Immunology
Ilaria Vicenti et al.
Summary: The study found that neutralizing antibody levels decrease over time in healthcare workers with mild or asymptomatic SARS-CoV-2 infection, but serum neutralizing activity remains detectable in the majority of cases after a median of 7 months from diagnosis.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Review
Immunology
Deborah Cromer et al.
Summary: The duration of immunity to COVID-19 and the risk of reinfection remain unclear. Immunity is crucial for long-term control of the pandemic, but studies suggest a decline in antibody responses and an increase in documented cases of reinfection with SARS-CoV-2. Understanding memory responses and immune control dynamics is essential for designing vaccines and predicting the future trajectory of the pandemic.
NATURE REVIEWS IMMUNOLOGY
(2021)
