期刊
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
卷 107, 期 -, 页码 53-58出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2021.04.046
关键词
Critical pertussis; Absolute neutrophil count; Leukocytosis
This study aimed to identify risk factors and outcomes of critical pertussis in children under 13 years old. Results showed that higher white blood cell count, absolute lymphocyte count, and absolute neutrophil count were significant predictors of critical pertussis.
Objectives: To identify risk factors and outcomes of patients with critical pertussis. Design: Retrospective observational cohort study. Setting: Sultan Qaboos University Hospital and The Royal Hospital, Muscat, Oman. Subjects: Children aged <13 years presenting to the emergency departments and diagnosed with laboratory-confirmed pertussis by polymerase chain reaction between January 2013 and December 2018. Measurements and main results: In total, 157 patients were diagnosed with pertussis, of which 12% (n = 19) had critical pertussis. Patients with critical pertussis had a higher white blood cell count (WBCC) [adjusted odds ratio (aOR) 1.05; 95% confidence interval (CI) 1.02-1.08; P = 0.003], absolute lymphocyte count (ALC) (aOR 1.08; 95% CI 1.03-1.15; P = 0.004) and absolute neutrophil count (ANC) (aOR 1.05; 95% CI 1.01-1.10; P = 0.032) than patients with non-critical pertussis, even after multi-variate adjustment. The area under the curve for discriminatory accuracy of laboratory variables was 0.75 (95% CI 0.65-0.85), 0.74 (95% CI 0.64-0.84) and 0.72 (95% CI 0.60-0.83) for maximum WBCC, ALC and ANC, respectively, with Youden's cut-off values of 31.5 x 10(9)/L, 19.9 x 10(9)/L and 5.0 x 10(9)/L, respectively. Conclusions: In children, higher WBCC, ALC and ANC were significant predictors of critical pertussis. A cut-off level of 31.5 x 10(9)/L for WBCC was associated with critical pertussis. (C) 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
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