期刊
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
卷 110, 期 -, 页码 403-409出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2021.07.057
关键词
Tuberculosis; 7-year recurrence; longitudinal study; China
The study conducted in Jiangxi Province, China, found a significantly higher recurrence rate among previously successfully treated TB patients, especially in the age range of 34-73 years and among current smokers.
Objectives: To determine tuberculosis (TB) recurrence in previously successfully treated patients in a routine program setting and baseline characteristics associated with TB recurrence. Methods: A prospective longitudinal study in Jiangxi Province, China. Patients, >= 14 years old, were consecutively registered and were followed up for seven years to assess TB recurrence against a patients' individual baseline data that had been entered into a database at TB registration. Results: There were 800 TB patients registered at baseline, and 634 (79.2%) of them completed antiTB treatments. Fifty-nine (9.3%) died, and 21 (3.3%) were lost to follow-up over the follow-up period. There were 96 patients with recurrent episodes (total incidence 15.2% or annual incidence 2,200/100,000). Of the recurrent cases, 53 (55.2%) happened within 2-year after completion of anti-TB treatments. After controlling confounding factors, the risk of TB recurrence was significantly higher in the age range 34-73 years (P<0.01) and current smokers (P<0.01). Conclusions: Overall recurrence rate among previously treated TB patients was much higher than the initial incidence in the same population (61-98/100,000) and settings with similar TB incidence. TB programs should consider closer monitoring of these patients for early detection of recurrence. Particular attention should be given to those between 34-73 years and those who use tobacco products. (C) 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
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