期刊
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
卷 155, 期 1, 页码 16-18出版社
WILEY
DOI: 10.1002/ijgo.13852
关键词
antenatal; child outcome; preterm delivery; prevention; progesterone
For women at high risk of preterm birth, particularly those with a significant history of previous preterm birth and a short cervix, vaginal progesterone treatment is recommended. However, for those where the effectiveness of progesterone is uncertain, it is not advised.
Women at high risk of preterm birth (either a previous spontaneous preterm birth and/or sonographic short cervix) with a singleton gestation should be offered daily vaginal progesterone or weekly 17-OHPC treatment to prevent preterm birth. Benefit is most significant in those with prior history of preterm birth and a short cervix. For women with a previous spontaneous preterm birth and a cervix >= 30 mm the effectiveness of progesterone is uncertain. In asymptomatic women with no prior history of previous preterm birth, no mid-trimester loss, or no short cervical length, progesterone therapy is not recommended for the prevention of preterm birth. For those with unselected multiple pregnancies, progesterone therapy is not recommended for the prevention of preterm birth. Daily vaginal progesterone or weekly 17-OHPC treatment can be used for the prevention of preterm birth. The preparation used should be decided by the woman and her clinician. There is no evidence of neurological or developmental benefit or harm in babies whose mothers use progestogens for preterm birth prevention antenatally.
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