期刊
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
卷 36, 期 11, 页码 1739-1747出版社
WILEY
DOI: 10.1002/gps.5594
关键词
ageing; cognitive decline; dementia; subjective cognitive complaint
资金
- National Health & Medical Research Council (NHMRC) of Australia Program Grants [ID350833, ID568969, APP1093083]
The study found a negative longitudinal association between increasing subjective cognitive complaints (SCCs) and decline in global cognition scores over 6 years, and participants reporting increasing SCCs had a nearly fourfold increased risk of developing dementia over 10 years.
Background Subjective cognitive complaints (SCCs) are a risk factor for dementia; however, little is known about their trajectories. Method Participants were 873 older adults (mage = 78.65 years; 55% females) from the Sydney Memory and Ageing Study that were followed-up biennially. SCCs were measured using the six-item Memory Complaint Questionnaire. Associations between initial level of SCC reporting, linear change in SCC reporting, and change in global cognition over 6 years was examined using latent growth curve analysis. Risk of dementia was examined over 10 years using Cox regression. Results After controlling for demographics, mood and personality, results revealed a negative longitudinal association between the slope of SCCs and the slope of global cognition scores (b = -0.01, p = 0.005, beta = -0.44), such that participants who reported increasing SCCs showed a steeper rate of decline in global cognition over 6 years. Cox regression also revealed participants who reported increasing SCCs had a nearly fourfold increased risk of developing dementia over 10 years (hazard ratio 3.70, 1.24-11.01). Conclusion This study explored whether initial levels of, and change in, SCCs over time are associated with both cognitive decline and risk of dementia. These findings are clinically relevant as GPs should note patients reporting increasing SCCs as they may be at greater risk of cognitive decline and incident dementia.
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