SARS-CoV-2 viral-load distribution reveals that viral loads increase with age: a retrospective cross-sectional cohort study

Article Immunology

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Viral Load in the Upper Respiratory Tract of Children and Adults With Early Acute Coronavirus Disease 2019 (COVID-19)

Stephanie Baggio et al.

Summary: The study found that there were no significant differences in SARS-CoV-2 RNA loads between children and adults in the early stages of COVID-19.

CLINICAL INFECTIOUS DISEASES (2021)

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Editorial Material Infectious Diseases

Combined throat/nasal swab sampling for SARS-CoV-2 is equivalent to nasopharyngeal sampling

A. L. M. Vlek et al.

Summary: The study compared the performance of combined throat/nasal sampling and nasopharyngeal sampling in detecting SARS-CoV-2. Results showed high concordance between the two sampling methods, with combined throat/nasal swabs demonstrating similar sensitivity to detect SARS-CoV-2 as nasopharyngeal swabs.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2021)

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Letter Immunology

College of American Pathologists (CAP) Microbiology Committee Perspective: Caution Must Be Used in Interpreting the Cycle Threshold (Ct) Value

Daniel Rhoads et al.

CLINICAL INFECTIOUS DISEASES (2021)

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Review Pediatrics

Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections

Petra Zimmermann et al.

Summary: The severity of COVID-19 differs between children and adults, with factors that put adults at higher risk and factors that protect children being the main reasons for this difference.

ARCHIVES OF DISEASE IN CHILDHOOD (2021)

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Article Immunology

Association Between Upper Respiratory Tract Viral Load, Comorbidities, Disease Severity, and Outcome of Patients With SARS-CoV-2 Infection

Helena C. Maltezou et al.

Summary: Analysis of 1122 COVID-19 patients revealed that high upper respiratory tract viral load was associated with older age, comorbidities, severe disease (COVID-19), intubation, and mortality, as well as longer stays in the intensive care unit and intubation time. High viral load was also more common in patients with chronic cardiovascular disease, hypertension, chronic pulmonary disease, immunosuppression, obesity, and chronic neurological disease.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Infectious Diseases