期刊
INTERNATIONAL JOURNAL OF EATING DISORDERS
卷 54, 期 9, 页码 1608-1618出版社
WILEY
DOI: 10.1002/eat.23570
关键词
anorexia nervosa; comorbidity; epidemiology; matched cohort design; register data
资金
- Jascha Fund Denmark
- A.P. MOller Fund Denmark
- Psychiatric Research Fund of the Region of Southern Denmark
The study found that patients with anorexia nervosa have a higher risk of developing any non-eating mental disorder in the first 2 years and 20 years after the initial diagnosis. Especially in the first few years after diagnosis, patients have a higher risk of comorbid mental disorders.
Objective Comorbid mental disorders in anorexia nervosa during long-term course require detailed studies. Method This matched cohort study was based on nationwide Danish register data of all patients born 1961-2008 with a first-time ICD-10 diagnosis of anorexia nervosa (AN) between 1994 and 2018 at age 8-32 and matched controls taken from all individuals without an eating disorder (ED). For nine categories of non-eating mental disorders, time from date of first AN-diagnosis (inclusion date) to time of first diagnosis, accounting for censoring, was studied by use of time-stratified Cox models. Results A total of 9,985 patients with AN (93.5% females) and 49,351 matched controls were followed for a median (IQR) of 9.0 (4.4-15.7) years. For patients, there was about 25% and 55% risk of receiving any non-ED disorder during the first 2 years and two decades after inclusion, respectively. A hazard ratio (HR) of seven for any non-ED was found for the first 12 months after inclusion, a ratio that reduced to two at five or more years after inclusion. During the first years, large HRs ranging in 6-9 were found for affective, autism spectrum, personality, and obsessive-compulsive disorders with the latter displaying the highest continuous increased risk. The HR at 12 months after inclusion was highest for any non-ED disorder and affective disorders in patients aged 8-13 at diagnosis. Discussion Comorbid mental disorders in AN are most frequently diagnosed in the first years after diagnosis of AN and on longer terms imply a double immediate risk.
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