期刊
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
卷 81, 期 7, 页码 545-578出版社
WILEY
DOI: 10.1002/jdn.10141
关键词
animal model; environment-genome interaction; neurodevelopmental disorders; psychiatric disorders; transcription; transcription factors
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Instituto Nacional de Ciencia e Tecnologia em Neuroimunomodulacao (INCT-NIM) [465489/2014-1]
Neurodevelopmental disorders are a diverse and prevalent group of psychiatric conditions characterized by impairments in the nervous system that onset during gestation and continue throughout postnatal life. Transcription factors play a critical role in different risk factors, organizing key developmental processes in a time and location-dependent manner, potentially serving as important mediators in the context of genome-environment interactions.
Neurodevelopmental disorders (NDDs) are a heterogeneous and highly prevalent group of psychiatric conditions marked by impairments in the nervous system. Their onset occurs during gestation, and the alterations are observed throughout the postnatal life. Although many genetic and environmental risk factors have been described in this context, the interactions between them challenge the understanding of the pathways associated with NDDs. Transcription factors (TFs)-a group of over 1,600 proteins that can interact with DNA, regulating gene expression through modulation of RNA synthesis-represent a point of convergence for different risk factors. In addition, TFs organize critical processes like angiogenesis, blood-brain barrier formation, myelination, neuronal migration, immune activation, and many others in a time and location-dependent way. In this review, we summarize important TF alterations in NDD and associated disorders, along with specific impairments observed in animal models, and, finally, establish hypotheses to explain how these proteins may be critical mediators in the context of genome-environment interactions.
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