期刊
INTERNATIONAL JOURNAL OF CARDIOLOGY
卷 343, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2021.09.011
关键词
Sex; Gender; Cardiac surgery; Mortality; Stoke; Myocardial infarction; Wound infection
资金
- British Heart Foundation
- NIHR Biomedical Research Centre at University Hospitals Bristol
- Weston NHS Foundation Trust
- University of Bristol
- British Heart Foundation [CH/1992027/7163] Funding Source: researchfish
Females undergoing CABG and valve surgery with CABG have a higher risk for short-term mortality and post-operative stroke compared to males, while no difference is found for isolated AVR. Long-term mortality is equivalent for both sexes.
Background: Despite advances in cardiac surgery, observational studies suggest that females have poorer postoperative outcomes than males. This study is the first to review sex related outcomes following both coronary artery bypass graft (CABG) and valve surgery with or without combined CABG. Methods: We identified 30 primary research articles reporting either short-term mortality (in-hospital/30 day), long-term mortality, and post-operative stroke, sternal wound infection and myocardial infarction (MI) in both sexes following CABG and valve surgery with or without combined CABG. Reported adjusted odds/hazard ratio were pooled using an inverse variance model. Results: Females undergoing CABG and combined valve and CABG surgery were at higher risk of short-term mortality (odds ratio (OR) 1.40; 95% confidence interval (CI) 1.32-1.49; I-2 = 79%) and post-operative stroke (OR 1.2; CI 1.07-1.34; I-2 = 90%) when compared to males. However, for isolated AVR, there was no difference found (OR 1.19; 95% CI 0.74-1.89). There was no increased risk in long-term mortality (OR 1.04; 95% CI: 0.93-1.16; I-2 = 82%), post-operative MI (OR 1.22; 95%CI: 0.89-1.67; I-2 = 60%) or deep sternal wound infection (OR 0.92; 95%CI: 0.65-1.03, I-2= 87%). No evidence of publication bias or small study effect was found. Conclusion: Females are at a greater risk of short-term mortality and post-operative stroke than males following CABG and valve surgery combined with CABG. However, there is no difference for Isolated AVR. Long-term mortality is equivalent in both sexes.
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