期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 183, 期 -, 页码 1309-1316出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.05.085
关键词
Chitosan; Chlorin e6; Photodynamic antibacterial properties
资金
- Science and Technology Program of Jiangsu Province [BE2017623]
- Jiangsu Agriculture Science and Technology Innovation Fund (JASTIF) [CX (18) 2025]
The study developed a novel photodynamic antibacterial agent CS-Ce6 conjugates by combining cationic polysaccharide chitosan with photosensitizer Chlorin e6 for combating gram-positive and gram-negative bacteria. The results demonstrated that the photodynamic antibacterial effect of CS-Ce6 conjugates was positively correlated with the degree of substitution (DS). This research highlights the potential of CS-Ce6 conjugates as effective photodynamic bactericidal agents.
The development of antibacterial agents with high bacteria-binding capability and antibacterial efficiency is highly desirable. Herein, cationic polysaccharide chitosan (CS) was combined with photosensitizer Chlorin e6 (Ce6) to construct a novel photodynamic antibacterial agent (CS-Ce6 conjugates) for combating gram-positive bacteria Staphylococcus aureus (S. aureus) and gram-negative bacteria Escherichia coli (E. coli). CS-Ce6 conjugates with different degrees of substitution (DS) were synthesized and characterized by a spectroscopic method and organic elemental analysis to understand the relationship between structure and antibacterial effect. CS-Ce6 conjugates revealed good reactive oxygen species (ROS) generation ability and photodynamic antibacterial effect. Meanwhile, they both were positively correlated with DS in the range of 4.81% similar to 11.56% resulting in stronger photodynamic antibacterial ability. These findings highlight that CS-Ce6 conjugates have the potential as an effective photodynamic bactericidal agent in the antibacterial field. (C) 2021 Elsevier B.V. All rights reserved.
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