3D-printed antioxidant antibacterial carboxymethyl cellulose/ε-polylysine hydrogel promoted skin wound repair

Developing a wound dressing for the treatment of large and irregular-shaped wounds remains a great challenge. Herein we developed novel printable bionic hydrogels with antibacterial and antioxidant properties which could effectively overcome the challenge by inhibiting inflammation and accelerating wound healing. The CMC/PL (CP) hydrogels were customized with glycidyl methacrylate (GMA) modified carboxymethyl cellulose (CMC) and epsilon-polylysine (epsilon-PL) via ultraviolet (UV) light polymerization using a 3D printer. Except for the high compression modulus (238 kPa), stable rheological properties, and effective degradability, these CP hydrogels also had an excellent inhibitory effect (95%) on both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Remarkably, CP hydrogels could remove the excessive reactive oxygen species (ROS) and protect the fibroblasts from damage. Compared with the commercial dressing (Tegaderm TM film), CP hydrogels showed a better ability to increase the expression of VEGF and CD31, accelerate granulation tissue regeneration, and promote wound healing. This work provides a new strategy to fabricate on-demand multi-functional hydrogels in the field of skin tissue engineering.

Automated summary

A novel printable bionic hydrogel with antibacterial and antioxidant properties was developed to effectively treat large and irregular-shaped wounds by inhibiting inflammation and accelerating wound healing. The hydrogels showed excellent properties such as high compression modulus, stable rheological properties, effective antibacterial effects, and the ability to remove excessive reactive oxygen species. In comparison to commercial dressings, these hydrogels demonstrated better expression of VEGF and CD31, accelerated granulation tissue regeneration, and promoted wound healing.