期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 183, 期 -, 页码 962-971出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.05.022
关键词
Chitosan; Alginate; Rifaximin; Core-shell nanoparticles; Antibacterial activities; Drug release; Kinetic study
资金
- Indian Institute of Technology Roorkee, India
- University Grants Commission (UGC), New Delhi
The study successfully synthesized rifaximin-loaded chitosan-alginate core-shell nanoparticles (Rif@CS/Alg-NPs) with excellent antibacterial activities against various bacteria. The nanoparticles showed no cytotoxicity towards human lung adenocarcinoma cell line A549 and exhibited drug release at different pH levels.
The present work aims to synthesize the rifaximin loaded chitosan-alginate core-shell nanoparticles (Rif@CS/Alg-NPs) for antibacterial applications. The core-shell nanoparticles (Rif@CS/Alg-NPs) were characterized by Fourier Transform Infrared (FT-IR) spectroscopy, Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), X-rays diffraction (XRD) and zeta analyzer. The antibacterial activities of Rif@CS/Alg-NPs were investigated against three species of bacteria namely Escherichia coil (E. coil), Pseudomonas aeruginosa (PA) and Bacillus haynesii (BH). Rif@CS/Alg-NPs exhibited outstanding antibacterial activities against E. coil, P. aeroginosa and Bacillus haynesii (BH) with 24 mm, 30 rnm and 34 mm zone of inhibitions, respectively. Cytotoxicity of Rif@CS/Alg-NPs was also evaluated against human lung adenocarcinoma cell line A549 and found to be nontoxic. The drug release behavior of Rif@CS/Alg-NPs was investigated at different pH levels and maximum drug release (80%) was achieved at pH (7.2). The drug release kinetic data followed the Higuchi (R-2 = 0.9963) kinetic model, indicating the drug release from Rif@CS/Alg-NPs as a square root of time-dependent process and diffusion controlled. Current research provides a cost-effective and green approach toward the synthesis of Rif@CS/Alg-NPs for its antibacterial applications. (C) 2021 Elsevier B.V. All rights reserved.
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