期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 183, 期 -, 页码 68-78出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.04.021
关键词
Anti-inflammatory; Artemisinin; Nanofiber; Wound dressing
资金
- Innovation Program for Chongqing's Overseas Returnees [cx2019090]
- Fundamental Research Funds for the Central Universities [XDJK2018B015]
- State Key Laboratory of Silkworm Genome Biology [sklsgb-2019KF13]
The combination of PLGA/SF/ART2 composite membranes with anti-inflammatory properties can be an appropriate dressing for chronic wound healing.
Combining biodegradable materials with natural plant components for wound dressing has been receiving significant attention. ART is a sesquiterpene lactone compound extracted from Artemisia annua L., possessing multiple pharmacological effects including antibacterial activity and anti-inflammatory property. Herein, the blended polylactic acid glycolic acid (PLGA)/silk fibroin (SF) membranes loaded with artemisinin (ART) are fabricated through electrospinning. With aid of SF, the fabricated membranes have a good sustained-release effect, and the accumulated ART release can reach 69% after three weeks. PLGA/SF/ART membranes exhibit favorable anti-inflammatory and cell compatibility in vitro evaluations. The in vivo experiment indicates that PLGA/SF/ART2 membranes can shorten the inflammation period and enhance skin regeneration in a full-thickness wound model through down-regulating the expressions of pro-inflammatory cytokines IL-1 beta and TNF-alpha. To sum up, the fabricated PLGA/SF/ART2 composite membranes with anti-inflammatory properties can be a proposal wound dressing for chronic wound healing. (C) 2021 Published by Elsevier B.V.
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