期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 182, 期 -, 页码 1259-1267出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.05.057
关键词
Dynamic covalently crosslinking; Keratin hydrogel; Disulfide bonds; Thiol group; Wool
资金
- Open Research Fund Program of Key Laboratory of Cleaner Production and Integrated Resource Utilization of China National Light Industry [CP-2020-YB5]
The DCC keratin hydrogels extracted by reducing agents show characteristics such as injectability, self-healing, self-adapting, biocompatibility, and redox-responsive capacity. The extracted type II neutral/alkali keratin plays a critical role in imparting the keratin hydrogels with reversible behaviors. Using a simple thioldisulfide bonds exchange strategy to prepare DCC keratin hydrogels avoids the extra introduction of chemical crosslinking agents.
Dynamic covalently crosslinking (DCC) hydrogels can mimic extracellular matrix and have the functions such as self-healing, self-adapting, and shape memory. The DCC keratin hydrogels based on thiol group-disulfide bonds exchange strategy have no reports so far as we know. Herein, inspired by the rich content of the intramolecular disulfide bonds and free thiol groups in the keratins extracted by reducing agents, we report a simple thioldisulfide bonds exchange strategy for preparing the DCC keratin hydrogels. While the pH value of the keratin solution extracted by reducing agents was adjusted to 9.5-10.0, the keratin hydrogels showed the characteristic with injectability, self-healing, self-adapting, biocompatibility, and redox-responsive capacity. The extracted type II neutral/alkali keratin plays a critical role in imparting the keratin hydrogels with the reversibility behaviors due to that the keratins could build dynamic covalent bonds through thiol oxidation and disulfide exchange reactions in alkali conditions. This strategy provides an inspiration for forming DCC keratin hydrogel by avoiding the extra introduction of chemical crosslinking agents. (c) 2021 Published by Elsevier B.V.
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