期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 183, 期 -, 页码 1222-1235出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.05.034
关键词
Titanium; Catechol; Antibacterial coatings
资金
- Basque Government [ZE2019/00012, 01-AF-W2-2018-00002]
- Department of Development and Infrastructures of the University of the Basque Country
- i + Med S. Coop.
- Ministerio Ciencia, Innovacion, Universidades [RTI2018-096862-B-100, GR18153]
- Junta de Extremadura [RTI2018-096862-B-100, GR18153]
- FEDER (Fondo Europeo de Desarrollo Regional Una manera de hacer Europa) [RTI2018-096862-B-100, GR18153]
Different polymeric antibacterial coatings were developed and analyzed for Ti6Al4V surface covering in this study, showing good cytocompatibility and antibacterial properties, which confirms their effectiveness against bacterial infections for future applications in protecting biomedical implants.
Bacterial contamination in implanted biomedical devices is a critical daily concern. The most used material for permanent implant in biomedical field is Ti6Al4V alloy due to its beneficial mechanical properties and high biocompatibility. Accordingly, in this work different polymeric antibacterial coatings poly(N-vinyl pyrrolidone) (PVP), hyaluronic acid (HA) and chitosan (CHI) were developed and comparatively analysed for Ti6Al4V surface covering. The adhesion of these coatings to Ti6Al4V substrates were carried out after the conjugation of these polymers with the so well-known bioadhesive properties of catechol (CA) anchor group. These surface modifica-tions were characterized by X-ray photoelectronic spectroscopy, contact angle measurements and atomic force microscopy. In addition, the stability of CA-conjugated polymeric coatings was compared with the coatings formed with unconjugated polymers. Finally, the cytocompatibility and antibacterial properties against gram positive and gram-negative strains on coated Ti6Al4V substrates were assessed confirming the effectiveness of these polymeric coatings against bacterial infections for future applications in protecting biomedical implants. (c) 2021 Elsevier B.V. All rights reserved.
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