Facile preparation of chitosan-dopamine-inulin aldehyde hydrogel for drug delivery application

Chitosan-based hydrogels are a suitable and versatile system for the design of localized and controlled drug delivery systems. In the current study, a hydrogel based on chitosan (CS), Dopamine (DA), and Inulin aldehyde (IA) was fabricated without the further use of catalyst or initiators. The effect of the IA contents as a crosslinking agent on the properties of the prepared hydrogel was studied. The crosslinking reaction between CS and IA was verified by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). Various characteristics of the CS/DA/IA hydrogels were further assessed utilizing swelling experiment, in vitro drug release, in vitro cytotoxicity assay. The drug-loaded hydrogels represented the sustained release of Indomethacin according to the in vitro drug release test in acidic (pH = 4), basic (pH = 10) medium as well as physiological condition (pH = 7). Finally, the CS/DA/IA hydrogels exhibited appropriate cytocompatibility against the L-929 fibroblast cell line according to the direct contact MTT assay.

Automated summary

Chitosan-based hydrogels are explored as a versatile system for localized and controlled drug delivery, with the study demonstrating the successful preparation of CS/DA/IA hydrogels for sustained release of Indomethacin. The interaction between chitosan and inulin aldehyde as a crosslinking agent is verified through various analyses, while the hydrogels also exhibit good cytocompatibility against fibroblast cell line according to MTT assay.