4.7 Article

Prolonged release and shelf-life of anticoagulant sulfated polysaccharides encapsulated with ZIF-8

期刊

出版社

ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.05.007

关键词

Metal-organic frameworks; ZIF-8; Anticoagulant; Sulfated polysaccharides; Hyaluronic acid

资金

  1. National Natural Science Foundation of China [22007049]
  2. Natural Science Foundation of Jiangsu Province [BK20200728, BK20200718]
  3. Natural Science Research Project of Jiangsu Higher Education Institutions [19KJB150013]

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Natural active polysaccharides are gaining attention in pharmaceutical industries for their biological activities, while metal-organic frameworks (MOFs) help deliver cargo to specific locations, protecting drugs and improving therapeutic effectiveness.
Natural active polysaccharides are attracting increased attention from pharmaceutical industries for their valuable biological activities. However, the application of polysaccharides has been restricted due to their relatively large molecular weight, complex structure, and instability. Metal-organic frameworks (MOFs) have emerged to help deliver cargo to specific locations, achieving the objectives of eliminating the potential damage to the body, protecting the drugs, and improving therapeutic effectiveness. Here, a pH-responsive zeolitic imidazolate framework (ZIF-8) was synthesized to encapsulated three sulfated polysaccharides (heparin, fucan sulfate, fucosylated chondroitin sulfate) and a non-sulfated polysaccharide, hyaluronic acid. The resulting polysaccharides@ZIF-8 biocomposites showed differences in terms of morphology, particle size, encapsulation, and release efficiency. These biocomposites retained antithrombotic activity and the framework ZIF-8 effectively protected these polysaccharides from degradation and prolonged shelf-life of the anticoagulants from the unfavorable environment. (c) 2021 Published by Elsevier B.V.

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