期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 182, 期 -, 页码 1820-1831出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.05.167
关键词
pH-sensitive dye; Wound dressing; N-methacylated chitosan
资金
- Academy of Scientific Research & Technology of Egypt
- Institute of Fundamental Technological Research, Poland, Polish Academy of Sciences
- National Research Centre, Egypt
The study developed a multifunctional wound dressing using red cabbage extract as a natural pH sensitive indicator and chitosan-based hydrogel, achieving smart therapeutic and comfortable properties. By adjusting the crosslinking method and structure, the hydrogel showed superior mechanical and swelling properties, with color changes indicating the status of the wound.
Developing a multifunctional wound dressing that protects, cures and indicates the healing progress, is a new approach of investigation. Red cabbage extract (RCE), consisting of bioactive compounds that have antioxidant, antiinflammatory, anti-carcinogenic, bactericidal, antifungal, and antiviral activities, was utilized as a natural pH sensitive indicator. Chitosan-based hydrogel, encapsulating RCE, was developed to obtain a smart therapeutic pH sensitive wound dressing as antimicrobial bio-matrix provides a comfortable cushion for wound bed and indicates its status. Methacrylated-chitosan was crosslinked by different concentrations of methylenebisacrylamide (MBAA) by which hydrogel mechanical and morphological properties were tuned. The proposed mechanism for hydrogel formation was confirmed by FT-IR. The coloristic properties of the RCE and the changes in color intensity as a function of pH were confirmed by UV-Vis spectroscopy. The effect of MBAA on the mechanical, swelling, release and morphological properties of hydrogel were investigated. MBAA (2.5% wt/v) in 2% wt/v chitosan showed preferable mechanical (20 KPa), swelling (1294% at pH 8 +/- 0.2), and release (prolonged up to 5 days) properties. Hydrogel matrices, loaded on cotton gauze submerged in different pH buffer solutions, showed explicit color changes from green to red as pH changed from 9 to 4. (c) 2021 Elsevier B.V. All rights reserved.
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