Chemosensitivity assessments of curdlan-doped smart nanocomposites containing erlotinib HCl

Curdlan (CN)-doped montmorillonite/poly(N-isopropylacrylamide-co-N,N'-methylene-bis-acrylamide) [CN/MT/P(NIPA-co-MBA)] smart nanocomposites (NCs) were developed for efficient erlotinib HO (ERL) delivery to lung cancer cells. The placebo NCs demonstrated excellent biodegradability, pH/therrno-responsive swelling profiles and declined molar mass ((M) over barc) between the crosslinks with increasing temperature. The XRD, MR, DSC, TGA, and SEM analyses revealed the architectural chemistry of these NC scaffolds. The NCs loaded with ERL (F-1-F-3) displayed acceptable diameter (734-1120 nm) and zeta potential (-1.16 to -11.17 my), outstanding drug entrapping capability (DEE, 78-99%) and sustained biphasic ERL elution patterns (Q(sh), 53-91%). The ERL release kinetics of the optimal matrices (F-3) obeyed Higuchi model and their transport occurred through anomalous diffusion. The mucin adsorption behaviour of these matrices followed Freudlich isotherms. As compared to pure ERl, the formulation (F-3) displayed an improved anti-proliferative potential and induced apoptosis more effectively on A549 cells. Thus. the CN-doped smart NCs could be utilized as promising drug-cargoes for lung cancer therapy. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

Smart nanocomposites containing Curdlan (CN) were developed for efficient delivery of erlotinib to lung cancer cells, showing excellent drug entrapment capability and sustained release patterns. These nanocomposites have the potential to be promising drug carriers for lung cancer therapy.