Antimicrobial effect of auranofin against Acanthamoeba spp.

Acanthamoebae are opportunistic pathogens that cause serious infections, including Acanthamoeba keratitis, a sight-threatening disease affecting mainly contact lens wearers, and granulomatous amoebic encephalitis, an infection of the central nervous system that occurs mostly in immunocompromised individuals. Although these infections are rare, they are a challenge for healthcare providers. In the last decade, the search for and implementation of novel treatment approaches against these parasites and the infections they cause have intensified, but current options are still unsatisfactory. The aim of this study was to investigate the in vitro activity of the gold-based compound auranofin against Acanthamoeba spp. The study showed that auranofin has potent antimicrobial activity against Acanthamoeba spp., with an IC50 ranging from 2.9 to 3.48 mu M, and thus may be useful in the prevention and control of Acanthamoeba infections. (C) 2021 The Authors. Published by Elsevier Ltd.

Automated summary

Acanthamoebae are opportunistic pathogens that can cause serious infections, including keratitis and encephalitis, and auranofin has shown potent antimicrobial activity against Acanthamoeba spp. in vitro, potentially aiding in the prevention and control of infections.