Gastrodia remodels intestinal microflora to suppress inflammation in mice with early atherosclerosis

Atherosclsis is a critical actuator causing cardiac-cerebral vascular disease with a complicated pathogeneon, refered to the disorders of intestinal flora and persistent inflammation. Gastrodin (4-(hydroxymethyl) phenyl beta-D- Glucopyranoside) is the most abundant glucoside extracted from the Gastrodia elata, which is a traditional Chinese herbal medicine for cardiac-cerebral vascular disease, yet its mechanisms remain little known. In the present study, the gastrodia extract and gastrodin attenuate the lipid deposition and foam cells on the inner membrane of the inner membrane of the thoracic aorta in the early atherosclerosis mice. Blood lipid detection tips that TC and LDL-C were reduced in peripheral blood after treatment with the gastrodia extract and gastrodin. Furthermore, unordered gut microbes are remodeled in terms of bacterial diversity and abundance at family and genus level. Also, the intestinal mucosa damage and permeability were reversed, accompanied with the reducing of inflammatory cytokines. Our findings revealed that the functions of gastrodia extract and gastrodin in cardiaccerebral vascular disease involved to rescued gut microbes and anti-inflammation may be the mechanism of remission lipid accumulation.

Automated summary

The study demonstrates that gastrodia extract and gastrodin alleviate lipid deposition and foam cells on the inner membrane of the thoracic aorta in early atherosclerosis mice, regulating blood lipids and reshaping gut microbiota diversity. Additionally, they reverse intestinal mucosal damage, reduce inflammatory cytokines, and potentially act through gut microbe rescue and anti-inflammatory effects to alleviate lipid accumulation in cardiovascular and cerebrovascular diseases.