期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 96, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.intimp.2021.107754
关键词
Galangin; Imiquimod-induced; Psoriasis; Pro-inflammatory cytokines; NF-kappa B pathway; Oxidative-nitrosative stress
资金
- Council of Scientific and Industrial Research (CSIR), New Delhi, India [31/014(2683)/2016-EMR-I]
- Department of Science and Technology (DST), New Delhi, India [IF160504]
- ICMR, New Delhi, India
- CSIR-IICT [IICT/Pubs./2021/039]
The study demonstrated that galangin (GAL) has a significant protective effect on skin inflammation induced by psoriasis-like symptoms, possibly through modulation of inflammatory pathways and oxidative stress. Galangin also regulated protein levels and antioxidant markers, showing potential for treating psoriasis.
Psoriasis is a most common chronic autoimmune-arbitrated cutaneous inflammatory skin disorder by unclear pathogenesis. In this current study we demonstrated the effect of galangin (GAL) on imiquimod (IMQ)-induced psoriasis-like skin inflammation and decipher its possible protective mechanism which has not been investigated. The in vivo results revealed that GAL at 1% w/w and 2% w/w for six consecutive days markedly reduced IMQ-induced PASI scoring, skin, ear thickness, hematological markers, levels of nitrites, TBARS, MPO, histopathological, as well modulated the protein levels of pro-inflammatory mediators of COX-2, iNOS, NF-kappa B pathway and pro-inflammatory cytokines IL-17, IL-23, IL-1 beta in the skin and also IL-6, TNF-alpha in both skin and serum. Besides, GAL restored the levels of antioxidants markers such as SOD, CAT, GST, GSH, GR and Vit-C, anti-inflammatory cytokine of IL-10, and the protein levels of Nrf2/HO-1 in the skin compared to the IMQ group. Finally, our study demonstrates that GAL exerted its protective effect by up-regulating the anti-inflammatory and the antioxidant markers against psoriasis pre-clinical models indicating its potency for treating psoriasis in humans.
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