期刊
INTERNATIONAL DAIRY JOURNAL
卷 120, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.idairyj.2021.105091
关键词
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资金
- National Natural Science Foundation of China [31370502]
- Ministry of Science and Technology of the People's Republic of China [2013BAD18B03, 2018YFC1604302]
- China Scholarship Council [202008210391]
- Shenyang Science and Technology Bureau [Y17-0-028]
- Liaoning Province Educational Department [XLYC1902083]
A study identified 63 different lipids in bovine colostrum and bovine milk using mass spectrometry, and selected 4 potential lipid biomarkers. Further analysis demonstrated the high reliability and stability of these markers, with a good classification performance indicated in ROC curve analysis.
Sixty-three significantly different lipids from bovine colostrum (BC) and bovine milk (BM) were quan-tified using ultra-high-performance liquid chromatography-Q exactive orbitrap-mass spectrometry lip-idomics and selected based criteria that included area under curve (AUC) value of the receiving operator characteristic (ROC) curve analysis >0.9. Four potential lipid biomarkers, including two up-regulated lipids, namely PE (P-16:0/22:5), and PE (P-16:0/20:4), and two down-regulated lipids, Hex2Cer (d14:0/ 24:0), and Hex2Cer (d15:0/24:1), were selected as a potential lipid biomarkers for further analysis. The orthogonal projections to latent structures-discriminate analysis (OPLS-DA), permutation tests of OPLS-DA, and receiving operator characteristic (ROC) curve analysis were further implemented to validate the reliability and stability of the potential lipid biomarkers. The four lipid biomarkers had an AUC value of 1 in the ROC curve analysis, showing a good classification performance. These results could contribute to purity analysis of BC products and a theoretical basis for the detection of lipids over lactation. (c) 2021 Elsevier Ltd. All rights reserved.
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