期刊
FITOTERAPIA
卷 111, 期 -, 页码 154-159出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2016.04.009
关键词
Yucca gloriosa L.; Asparagaceae; Yuccalides A-C; Spiro-structure; Anti-inflammatory
Three new phenolic compounds, yuccalides A-C (1-3), were isolated from the roots of Yucca gloriosa L., along with four known compounds (4-7). The structures of the new compounds were established by extensive NMR spectroscopic analyses. Inducible nitric oxide synthase (iNOS) mRNA levels induced by lipopolysaccharide (LPS) in mouse macrophage-like RAW 264.7 cells were effectively suppressed by compounds 2, 4, and 6, all of which had the (2R*, 3R*)-configuration. IL-1 beta and IL-6 mRNA levels induced by LPS were significantly attenuated by compounds 4, 5, and 6, but not by 2. (C) 2016 Elsevier B.V. All rights reserved.
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