期刊
FITOTERAPIA
卷 109, 期 -, 页码 99-105出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2015.12.006
关键词
Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao; Stem; Oleanane type; Saponin; HepG2 cells; Triglyceride accumulation inhibitory effects
资金
- Program for New Century Excellent Talents in University [NCET-12-1069]
- Program for Tianjin Innovative Research Team in University [TD12-5033]
- Program for Important Drug Develop of MOST, China [2013ZX09402201]
Astragalus membranaceus is a Traditional Chinese Medicine (TCM) belonging to the Leguminosae family. It has been used as antidiabetic, cardioprotective, and hepatoprotective in the TCM clinic. From the stems of A. membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, 14 oleanane type saponins (1-14) including eight new ones, astroolesaponins A (1), B (2), C-1 (3), C-2 (4), D (5), E-1 (6), E-2 (7), and F (8) were obtained, and their structures were elucidated by chemical and spectroscopic methods. Compounds 1-5, 7, 8,11, and 13 showed decreased effects on triglyceride levels in sodium oleate induced HepG2 cells. (C) 2015 Elsevier B.V. All rights reserved.
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