4.4 Article

Diagnostic yield of small bowel capsule endoscopy in obscure gastrointestinal bleeding: a real-world prospective study

期刊

INTERNAL AND EMERGENCY MEDICINE
卷 17, 期 2, 页码 349-358

出版社

SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s11739-021-02791-z

关键词

Small Bowel Capsule Endoscopy (SBCE); Endoscopy; Bleeding; Diagnostic yield; Dedicated gastroenterologist; Obscure gastrointestinal bleeding (OGIB)

资金

  1. Universita degli Studi di Roma Tor Vergata within the CRUI-CARE Agreement

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In a real-world prospective study, small bowel capsule endoscopy (SBCE) demonstrated a high diagnostic yield in patients with obscure gastrointestinal bleeding (OGIB), detecting clinically relevant lesions in the majority of cases. SBCE was found to be valuable in determining the diagnostic work-up and clinical outcome in patients with OGIB.
Small bowel capsule endoscopy (SBCE) visualizes the small bowel (SB) mucosa. Gastrointestinal (GI) bleeding from SB accounts for the majority of SBCE indications. We aimed to assess, in a real-world prospective study, the diagnostic yield of SBCE in a cohort of consecutive patients with obscure gastrointestinal bleeding (OGIB). Secondary end point was to assess the frequency of adverse events and the role of SBCE in determining the diagnostic work-up and clinical outcome. From 2016 to 2018, all patients referred for SBCE examination were enrolled. Indication for SBCE was re-assessed by 2 dedicated gastroenterologists. Inclusion criteria: (1) age >= 18 and <= 85 years; (2) diagnosis of OGIB; 3) non-diagnostic standard bidirectional endoscopy; (4) informed consent. Exclusion criteria: (1) deglutition impairment; (2) SBCE contraindications; (3) pregnancy. The cohort included 50 patients [males 18 (36%), age 68 (27-83)]. SBCE indication: patients with ongoing overt OGIB (Group A) (n = 11; 22%), previous overt OGIB (Group B) (n = 14; 28%), occult bleeding (with Iron Deficiency Anaemia) (Group C) (n = 25; 50%). SBCE detected clinically relevant lesions in 46 (92%) cases. Clinically relevant lesions were more frequent in Group C (24/25; 96%), followed by Group A (10/11; 91%) and Group B (12/14; 85.5%). After SBCE, treatment was medical (60%); endoscopic (14%), surgical (36%) or conservative (18%). Clinical follow-up showed complete resolution in 63.2%, partial/absent resolution in 18.4% of cases. In a prospective study, the high diagnostic yield of SBCE supports its role as first-line investigation in patients with OGIB. However, this achievement requires an accurate and timely assessment by dedicated gastroenterologists.

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