期刊
FITOTERAPIA
卷 108, 期 -, 页码 55-61出版社
ELSEVIER
DOI: 10.1016/j.fitote.2015.11.011
关键词
Red peony root; Paeonia lactiflora; Monoterpene derivatives; Anti-allergic activity
资金
- JSPS KAKENHI [24406005, 15H05268]
- Japan Agency for Medical Research and Development [15ak0101034h0001]
- Grants-in-Aid for Scientific Research [24406005, 15H05268] Funding Source: KAKEN
The methanolic extract and its subfractions from red peony root, the dried roots of Paeonia lactiflora Pallas showed potent antiallergic effects, as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 16 monoterpene derivatives, including 3 new compounds, paeoniflorol (1), 4'-hydroxypaeoniflorigenone (2) and 4-epi-albiflorin (3), together with 13 known ones (4-16). The chemical structures of the new compounds were elucidated on the basis of spectroscopic and chemical evidences. Among the isolated monoterpene derivatives, nine compounds showed potent anti-allergic effects and compound 1 was the most effective. A primary structure-activity relationship of monoterpene derivatives was discussed. (C) 2015 Elsevier B.V. All rights reserved.
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