期刊
FITOTERAPIA
卷 112, 期 -, 页码 74-84出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2016.04.023
关键词
Cardenolides; Apocynaceae; Anticancer; Structures
资金
- Tianjin Science and Technology Research Programs of Application Foundation and Advanced Technology [14JCYBJC29000]
Cardenolides, as a group of natural products that can bind to Na+/K+-ATPase with an inhibiting activity, are traditionally used to treat congestive heart failure. Recent studies have demonstrated that the strong tumor cytotoxicities of cardenolides are mainly due to inducing the tumor cells apoptosis through different expression and cellular location of Na+/K+-ATPase alpha-subunits. The leaves, flesh, seeds and juices of numerous plants from the genera of Nerium, Thevetia, Cerbera, Apocynum and Strophanthus in Apocynaceae family, are the major sources of natural cardenolides. So far, 109 cardenolides have been isolated and identified from this family, and about a quarter of them are reported to exhibit the capability to regulate cancer cell survival and death through multiple signaling pathways. In this review, we compile the phytochemical characteristics and anticancer activity of the cardenolides from this family. (C) 2016 Elsevier B.V. All rights reserved.
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