4.5 Article

Pharmacokinetic-Pharmacodynamic Model of Vedolizumab for Targeting Endoscopic Remission in Patients With Crohn Disease: Posthoc Analysis of the LOVE-CD Study

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Pharmacology & Pharmacy

Modelling of the relationship between infliximab exposure, faecal calprotectin and endoscopic remission in patients with Crohn's disease

Erwin Dreesen et al.

Summary: Evidence for the benefits of pharmacokinetic (PK) and pharmacodynamic (PD) monitoring of infliximab in patients with Crohn's disease (CD) remains scarce. By developing a population (pop)PK/PD model, the study aimed to characterize the infliximab dose-exposure-biomarker-response relationship. Results showed that infliximab clearance and baseline fCal were influenced by various factors, with large interpatient PK and PD variability resulting in a flat dose-response curve. Model-informed dose optimization may improve the effectiveness of infliximab therapy.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2021)

Article Gastroenterology & Hepatology

Dose optimisation for Loss of Response to Vedolizumab - Pharmacokinetics and Immune Mechanisms

Bella Ungar et al.

Summary: The study found that pre-optimisation levels of vedolizumab are positively associated with therapy outcomes in patients undergoing dose optimisation. Higher pre-escalation levels may indicate less severe disease and a higher likelihood of subsequent response after therapy escalation.

JOURNAL OF CROHNS & COLITIS (2021)

Article Gastroenterology & Hepatology

Vedolizumab treatment persistence and safety in a 2-year data analysis of an extended access programme

Silvio Danese et al.

Summary: In the vedolizumab extended access programme, most patients showed persistence with treatment even after reducing dosing frequency to every 8 weeks, with low rates of relapse and re-escalation to the higher dosing frequency of every 4 weeks. The safety profile of vedolizumab remained consistent with previous reports, with infrequent adverse events reported.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2021)

Article Gastroenterology & Hepatology

Vedolizumab Concentrations Are Associated with Long-Term Endoscopic Remission in Patients with Inflammatory Bowel Diseases

Andres J. Yarur et al.

DIGESTIVE DISEASES AND SCIENCES (2019)

Article Gastroenterology & Hepatology

Early vedolizumab trough levels predict combined endoscopic and clinical remission in inflammatory bowel disease

Jurij Hanzel et al.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2019)

Article Gastroenterology & Hepatology

Vedolizumab Induces Endoscopic and Histologic Remission in Patients With Crohn's Disease

Mark Lowenberg et al.

GASTROENTEROLOGY (2019)

Article Gastroenterology & Hepatology

Endoscopic, Radiologic, and Histologic Healing With Vedolizumab in Patients With Active Crohn's Disease

Silvio Danese et al.

GASTROENTEROLOGY (2019)

Article Gastroenterology & Hepatology

Evidence to Support Monitoring of Vedolizumab Trough Concentrations in Patients With Inflammatory Bowel Diseases

Erwin Dreesen et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2018)

Article Gastroenterology & Hepatology

Exposure-efficacy Relationships for Vedolizumab Induction Therapy in Patients with Ulcerative Colitis or Crohn's Disease

Maria Rosario et al.

JOURNAL OF CROHNS & COLITIS (2017)

Article Gastroenterology & Hepatology

The Real-World Effectiveness and Safety of Vedolizumab for Moderate-Severe Crohn's Disease: Results From the US VICTORY Consortium

Parambir S. Dulai et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2016)

Review Gastroenterology & Hepatology

An Overview of the Mechanism of Action of the Monoclonal Antibody Vedolizumab

Tim Wyant et al.

JOURNAL OF CROHNS & COLITIS (2016)

Article Gastroenterology & Hepatology

Population pharmacokinetics-pharmacodynamics of vedolizumab in patients with ulcerative colitis and Crohn's disease

M. Rosario et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2015)

Article Gastroenterology & Hepatology

Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target

L. Peyrin-Biroulet et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2015)

Article Medicine, General & Internal

Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis

Brian G. Feagan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Medicine, General & Internal

Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease

William J. Sandborn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Biochemical Research Methods

Antibodies to constant domains of therapeutic monoclonal antibodies: Anti-hinge antibodies in immunogenicity testing

Theo Rispens et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2012)

Article Biochemical Research Methods

Measurement of serum levels of natalizumab, an immunoglobulin G4 therapeutic monoclonal antibody

Theo Rispens et al.

ANALYTICAL BIOCHEMISTRY (2011)

Article Pharmacology & Pharmacy

Importance of Shrinkage in Empirical Bayes Estimates for Diagnostics: Problems and Solutions

Radojka M. Savic et al.

AAPS JOURNAL (2009)

Article Pharmacology & Pharmacy

Population pharmacokinetic analysis of infliximab in patients with ulcerative colitis

Adedigbo A. Fasanmade et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2009)

Review Pharmacology & Pharmacy

Quantification of lean bodyweight

S Janmahasatian et al.

CLINICAL PHARMACOKINETICS (2005)

Article Gastroenterology & Hepatology

Development and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CD

M Daperno et al.

GASTROINTESTINAL ENDOSCOPY (2004)