期刊
INFLAMMATION
卷 44, 期 5, 页码 1713-1723出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-021-01484-1
关键词
Human saliva; Molecular diagnostics; RT-PCR; Biomarkers; Inflammation
资金
- Zum Heilen Diagnostic & Therapeutics Pvt. Ltd.
Saliva is increasingly studied as a non-invasive and stress-free diagnostic material, with RNA extracted from saliva being used for early disease detection through real-time reverse transcriptase polymerase chain reaction (RT-PCR). Assessing the host inflammatory response and its resolution at early stages can serve as a prognostic and predictive method for determining therapeutic response or disease progression. The potential of saliva as a specimen for diagnosing early inflammatory biomarkers using RT-PCR is fascinating and useful.
Nowadays human saliva is more frequently studied as a non-invasive, stress-free, and preferable diagnostic material than blood. Supporting evidences acknowledge saliva as a mirror that reflects the body's physical state. Numerous studies have also demonstrated the presence and use of RNA derived from saliva in the early diagnosis of disease by real-time reverse transcriptase polymerase chain reaction (RT-PCR). Assessing the host inflammatory response in patients and its resolution at an early stage can serve as a prognostic and predictive method in determining therapeutic response or disease progression. In this context, the potential of saliva as a specimen to diagnose early inflammatory biomarkers using RT-PCR seems fascinating and useful. Here, we review inflammatory biomarkers within the saliva, focusing on early detection of these biomarkers using RT-PCR and the factors influencing the quality of saliva specimen.
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