期刊
INDUSTRIAL CROPS AND PRODUCTS
卷 168, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.indcrop.2021.113577
关键词
Effervescence; Mechanochemical extraction; Ganoderma lucidum; Ganoderma acid; Response surface methodology; Natural medicine
资金
- Hangzhou Social Development of Scientific Research projects [20191203B13]
- General Program of public welfare research project of Zhejiang Province [LGF18H280006]
- National Natural Science Foundation of China [81573552]
- Hangzhou 131 Middleaged and Young Talent Training Plan (China) [3402017]
This study developed a simple, green, and low-consumption method for the extraction of ganoderic acids. The effects of different parameters on extraction efficiency were investigated, resulting in the highest yields achieved under specific conditions.
The aim of this work was to develop a simple, green and low-consumption method for the extraction of ganoderic acids. An in situ effervescence reaction-assisted mechanochemical extraction method was proposed, and the effects of independent variations in terms of sodium bicarbonate concentration, milling time, and liquid/solid ratio (mL/g) were investigated by means of a response surface methodology (RSM) Box-Behnken design (BBD). The highest yields of ganoderic acids were achieved by grinding a Ganoderma lucidum sample with sodium bicarbonate (372.60 mg/g) and citric acid for 0.87 min with a water to material ratio of 10.58 mL. The linear calibration ranges were from 0.01-5 mu g/mL for the six analytes and had good linearity with a correlation coefficient of determination higher than 0.9991. In addition, the obtained LODs of the six target analytes were 1.46 - 2.97 ng/mL, and the LOQs calculated as ten times the signal-to-noise ratio were 4.88 - 9.90 ng/mL. The proposed method was successfully applied to the Ganoderma lucidum samples.
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