A Review of the Selected and Newer Antiseizure Medications Used in Childhood Epilepsies

There have been additions of newer antiseizure medications in the armamentarium of clinicians for the management of epilepsy. The newer antiseizure medications have advantages of better tolerability, lesser adverse effects, and minimal drug interactions in comparison with conventional antiseizure medications. However, high cost and availability are concerns. There are also peculiar pharmacokinetic and pharmacodynamic considerations for the pediatric age, particularly in the context of age-dependent electroclinical syndromes and precision-based medicine. This review attempts to provide a comprehensive and pragmatic update on newer antiseizure medications.

Automated summary

Newer antiseizure medications offer advantages in terms of tolerability, adverse effects, and drug interactions compared to conventional medications, but concerns remain regarding high cost and availability. Unique pharmacokinetic and pharmacodynamic considerations are important for the pediatric population, especially in the context of age-dependent electroclinical syndromes and precision-based medicine. This review aims to provide a comprehensive update on newer antiseizure medications.