Recent Advances in Bronchopulmonary Dysplasia

Bronchopulmonary dysplasia (BPD) is a form of chronic lung disease that occurs in preterm infants, usually those receiving substantial respiratory support with either mechanical ventilation or supplementation with oxygen. The pathogenesis of BPD is multifactorial, and the clinical phenotype is variable. BPD is associated with substantial mortality and short- and long-term morbidity. The incidence of BPD has remained stable or increased, as advances in neonatal care have led to improved survival of more extremely preterm infants. Extensive basic science, translational, and clinical research focusing on BPD has improved the current understanding of the factors that contribute to BPD pathogenesis. However, despite a better understanding of its pathophysiology, BPD continues to be challenging to prevent and manage adequately. The current review aims to provide a clinically useful synopsis of evidence on the prevention and management of BPD in preterm infants.

Automated summary

Bronchopulmonary dysplasia (BPD) is a chronic lung disease that commonly occurs in preterm infants who require significant respiratory support. Despite improvements in neonatal care leading to increased survival rates, the incidence of BPD remains stable or even increasing. The pathogenesis of BPD is multifactorial, with high mortality rates, and prevention and management continue to be challenging.