期刊
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
卷 43, 期 6, 页码 724-730出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/08923973.2021.1973492
关键词
CD48; allergic rhinitis; non-allergic rhinitis; eosinophils; nitric oxide
资金
- Medical University of Silesia Katowice, Poland [KNW-2-K04/D/8/N]
This study found significantly higher sCD48 levels in NAR patients compared to PAR and healthy controls, with a significant correlation between sCD48 levels and eosinophils. ECP and eotaxin-1/CCL11 levels were also significantly higher in the NAR group.
Background CD48 is a costimulatory receptor of the immune response. Interactions between CD48 and CD244 (2B4) on mast cells and eosinophils suggest that these cells can act synergistically in the 'allergic effector unit' to promote inflammation. This report explores the role of CD48 in persistent allergic (PAR) and non-allergic rhinitis (NAR). Methods In this study, serum was obtained from 70 subjects (45 female, 64%; mean age, 36; range 18-70 years) to estimate the levels of sCD48 and two eosinophils-related parameters, ECP and eotaxin-1/CCL11. Twenty patients with PAR, 15 patients with NAR, and 35 healthy controls were included. The intensity of rhinitis symptoms was estimated by the Total Nasal Symptom Score. We also assessed the fractional exhaled nitric oxide bronchial and nasal fractions (FeNO) and neutrophil to lymphocyte (NLR) and eosinophil to lymphocyte (ELR) ratios. Results Significantly higher sCD48 serum levels were observed in the NAR group than in the PAR and control groups, and significant correlations were found between the serum level of sCD48 and the number and percentage of eosinophils. ECP and eotaxin-1/CCL11 serum levels were also found to be significantly higher in the NAR group. Conclusions CD48 may be involved in eosinophilic pathophysiological reactions in non-allergic rhinitis
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据