期刊
IMMUNOLOGY LETTERS
卷 236, 期 -, 页码 20-30出版社
ELSEVIER
DOI: 10.1016/j.imlet.2021.05.008
关键词
Cell therapy; Immunotherapy; Recurrent miscarriage; Recurrent pregnancy loss; Recurrent Implantation Failure
类别
资金
- Stem Cell Research Center (SCRC), Tabriz University of Medical Sciences, Tabriz, Iran [64,496]
Immunomodulatory and immunosuppressive therapies can manage reproductive failures by controlling immune cells, leading to improved pregnancy outcomes and live birth rates.
Maternal-fetal immune dysregulation is one of the risk factors that increases the probability of embryo rejection and reproductive failure. The stimulation of immunological tolerance and suppression of immunological rejection are prerequisites for protecting embryos and preventing immunological attacks. Hence, it appears that immunomodulatory and immunosuppressive therapies can manage reproductive failures by controlling immune cells. The current medical literature has shown that immunotherapy approaches and cell therapy have promising results in improving pregnancy outcomes and live birth rates. These outcomes are obtained by regulating maternal immune responses, and exerting positive effects on human reproductive processes.
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