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The three as: Alternative splicing, alternative polyadenylation and their impact on apoptosis in immune function*

期刊

IMMUNOLOGICAL REVIEWS
卷 304, 期 1, 页码 30-50

出版社

WILEY
DOI: 10.1111/imr.13018

关键词

alternative polyadenylation; alternative splicing; apoptosis; T cell activation

资金

  1. National Institute of General Medical Sciences [GM118048-S1, F31 GMGM140978, R35 GM118048]

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The latest advances in next-generation sequencing studies have revealed a high frequency of genes regulated by RNA processing mechanisms in the immune system, particularly alternative splicing and alternative polyadenylation. These mechanisms have the potential to alter protein identity, control protein abundance, localization, and association with other factors. This review focuses on how control of apoptosis by alternative splicing and alternative polyadenylation is utilized to tune cell fate during an immune response.
The latest advances in next-generation sequencing studies and transcriptomic profiling over the past decade have highlighted a surprising frequency of genes regulated by RNA processing mechanisms in the immune system. In particular, two control steps in mRNA maturation, namely alternative splicing and alternative polyadenylation, are now recognized to occur in the vast majority of human genes. Both have the potential to alter the identity of the encoded protein, as well as control protein abundance or even protein localization or association with other factors. In this review, we will provide a summary of the general mechanisms by which alternative splicing (AS) and alternative polyadenylation (APA) occur, their regulation within cells of the immune system, and their impact on immunobiology. In particular, we will focus on how control of apoptosis by AS and APA is used to tune cell fate during an immune response.

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