期刊
IMMUNOLOGICAL REVIEWS
卷 303, 期 1, 页码 23-34出版社
WILEY
DOI: 10.1111/imr.12988
关键词
antibody secretion; B cell differentiation; plasma cell; unfolded protein response
类别
资金
- National Health and Medical Research Council [1144905, 1155342, 1160830]
- National Health and Medical Research Council of Australia [1144905, 1155342, 1160830] Funding Source: NHMRC
This review discusses the gene regulatory network that controls ASC identity and function, with a focus on the processes influencing antibody transcription, translation, folding, modification, and secretion. It also addresses how ASCs have adapted their pathways to sustain high rates of antibody production and the roles of major ASC regulators in coordinating these processes.
Antibodies are an essential element of the immune response to infection, and in long-term protection upon re-exposure to the same micro-organism. Antibodies are produced by plasmablasts and plasma cells, the terminally differentiated cells of the B lymphocyte lineage. These relatively rare populations, collectively termed antibody secreting cells (ASCs), have developed highly specialized transcriptional and metabolic pathways to facilitate their extraordinarily high rates of antibody synthesis and secretion. In this review, we discuss the gene regulatory network that controls ASC identity and function, with a particular focus on the processes that influence the transcription, translation, folding, modification and secretion of antibodies. We will address how ASCs have adapted their transcriptional, metabolic and protein homeostasis pathways to sustain such high rates of antibody production, and the roles that the major ASC regulators, the transcription factors, Irf4, Blimp-1 and Xbp1, play in co-ordinating these processes.
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