期刊
FISH & SHELLFISH IMMUNOLOGY
卷 59, 期 -, 页码 268-275出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2016.10.051
关键词
Shrimp; WSSV; STAT; 1E1; Interaction; Transcription regulation
资金
- Major State Basic Research Development Program of China (973 Program) [2012CB114403]
- China Agriculture Research System-47
- National Natural Science Foundation of China [31001125, 31302209, 31472297]
- Scientific Research Foundation of Third Institute of Oceanography, SOA [2014020]
- Fujian Science and Technology Project [2015J05068]
STATs are a family of transcription factors that regulate a cascade of cellular processes including cell growth, differentiation, apoptosis and immune responses. However, they are usually targeted by viruses to assist infection. In this study, we identified that white spot syndrome virus (WSSV) immediate-early protein IE1 interacted with Litopenaeus vannamei STAT (LvSTAT) and thereby led to its phosphorylation activation. In addition, we demonstrated that LvSTAT could bind to the promoters of the viral immediate early genes wsv051 and iel through STAT-binding motifs in vitro and vivo, allowing the enhancement of their promoters' activities. Moreover, 1E1 could promote the transcriptional activation activity of LvSTAT to augment the transcription of wsv051 and iel. In conclusion, our findings revealed a novel linkage between WSSV IE1 and shrimp STAT, which was a clue to well understand how WSSV adopted the active strategies to modulate the shrimp signaling pathway. (C) 2016 Elsevier Ltd. All rights reserved.
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