期刊
FISH & SHELLFISH IMMUNOLOGY
卷 58, 期 -, 页码 370-379出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2016.09.044
关键词
Zebrafish; Phosvitin; Antibiotics; Antimicrobial peptide; Multi-drug resistance bacteria
资金
- Natural Science Foundation of China [U1401211]
- Ministry of Science and Technology of China [2012CB114404]
Pt5e, a mutant peptide derived from the C-terminal 55 residues of zebrafish phosvitin, has been suggested to be a novel antibacterial peptide. However, if it is applicable to clinical MDR bacteria remains to be tested. In this study, high-purity Pt5e was first expressed and purified by fusion with cationic elastin-like polypeptide. Pt5e was then shown to be capable of effectively killing all the five clinical MDR bacteria tested. PtSe kill the MDR bacteria at several levels, including inserting into the bacterial membranes, causing the membrane depolarization and permeabilization, and inducing the intracellular apoptosis/necrosis. All these data suggest that PtSe is a promising therapeutic potential as an antibiotics against clinical MDR bacteria. (C) 2016 Elsevier Ltd. All rights reserved.
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