4.6 Article

A 9.7-nTrms, 704-ms Magnetic Biosensor Front-End for Detecting Magneto-Relaxation

期刊

IEEE JOURNAL OF SOLID-STATE CIRCUITS
卷 56, 期 7, 页码 2171-2181

出版社

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSSC.2020.3043669

关键词

1/f noise; Magnetometers; Immune system; Magnetic sensors; Biosensors; Sensitivity; Magnetoresistance; Magnetic immunoassay (MIA); magnetic sensor; relaxometry; sensor analog front-end (AFE); Zoom ADC

资金

  1. National Science Foundation [ECCS-1454608]
  2. Qualcomm

向作者/读者索取更多资源

This article presents a low-noise magnetic sensor front-end with an 18-bit Zoom ADC for detecting temporal magnetic nanoparticle relaxation. Utilizing techniques like dynamic element matching and magnetoresistive correlated double sampling, it achieves state-of-the-art noise performance and a significantly improved figure-of-merit compared to previous sensor and AFE designs. Implemented in a 0.18um CMOS process, the design consumes 4.32mW from a 1.8V supply.
This article reports a low-noise magnetic sensor front-end with an 18-bit Zoom ADC for detecting temporal magnetic nanoparticle (MNP) relaxation. Techniques such as dynamic element matching (DEM) and magnetoresistive correlated double sampling (MRCDS) are proposed to remove the sensor and analog front-end (AFE) 1/f noise while a fast-settling Miller compensation (FSMC) technique is proposed to reduce the amplifier power. Collectively, these result in state-of-the-art input-referred noise performance (9.7 nT(rms)) and a figure-of-merit (FoM) that is 6.6x and 210x better than previously reported magnetic sensor and relaxation-based AFEs, respectively. A relaxation-based magnetic immunoassay (MIA) was performed to demonstrate the concept. This design is implemented in a 0.18-mu m CMOS process and consumes 4.32 mW from a 1.8-V supply.

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