期刊
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
卷 27, 期 4, 页码 -出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSTQE.2020.3020237
关键词
Imaging; Lipidomics; Probes; Image resolution; Fluorescence; Optical fibers; Autofluorescence; intravascular; plaque
资金
- National Natural Science Foundation of China (NSFC) [61627827, 61705068, 61331001, 81630046, 91539127]
- Science and Technology Planning Project of Guangdong Province, China [2015B020233016, 2014B020215003, 2014A020215031]
- Ph.D. Start-up Fund of Natural Science Foundation of Guangdong Province [2017A030310363]
A dual-modality endoscope probe with a diameter of 1 mm was proposed for simultaneously detecting the lipid core and intraplaque hemorrhage (IPH). The system composed of photoacoustic imaging (PAI) and near-infrared auto-fluorescence imaging (NIRAFI) markers was capable of accurately imaging IPH and lipid core expansion.
Intraplaque hemorrhage (IPH), which is a trigger and conveys all blood components into the plaque, influencing the cholesterol crystal formation and retention, haemoglobin and oxidative enzymes, and blood-borne proteolytic activity. IPH is one of the key determinants for plaque vulnerability. In this paper, we proposed a dual-modality endoscope probe with a diameter of 1 mm for simultaneously detecting the lipid core and IPH, our system was composed of photoacoustic imaging (PAI) and near-infrared auto-fluorescence imaging (NIRAFI). The lipid as endogenous marker of intravascular PAI could visualize the lipid distribution of atherosclerotic plaque, and bilirubin as the marker of intravascular NIRAFI was used to locate and quantify the IPH. The phantom and ex vivo rabbit aorta experiments had proved the feasibility and capability of the dual-mode probe for imaging IPH and lipid core expansion. And the results indicated that the dual-mode intravascular endoscope had the potential for accurately detecting IPH in atherosclerotic plaques.
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