期刊
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
卷 27, 期 5, 页码 -出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSTQE.2021.3060496
关键词
Strips; Immune system; Probes; Nanoparticles; Sensitivity; Optical sensors; Biomedical optical imaging; Mesoporous silica encapsulated up-converting nanoparticles; PCT quantification; up conversion luminescence (UCL) system; immunochromatography
This paper presents an up conversion luminescence (UCL) system based on immunochromatography for quantitative detection of Procalcitonin (PCT) in plasma. Using UCNPs@mSiO(2) as probes, the system can detect PCT concentration in the range of 1-200 ng/mL with a detection limit of 0.5 ng/mL, demonstrating great potential in infection monitoring and early diagnosis.
With the advancing of nanotechnology, nanomaterials based biosensors have been widely developed. Among them, optical biosensors stand out due to the high sensitivity and fast detection. In this paper, we demonstrate an up conversion luminescence (UCL) system based on immunochromatography by using core-shell mesoporous silica encapsulated up-converting nanoparticles (UCNPs@mSiO(2)) as probes for quantitative detection of Procalcitonin (PCT) in plasma. Compared with other structures, UCNPs@mSiO(2) possess both great biocompatibility and strong luminous intensity, which is extremely ideal in immune detection. We further design a portable UCL reader for optical signal collecting and processing. As a result, the UCNPs@mSiO(2) based lateral flow system can quantify PCT concentration with a range of 1-200 ng/mL, and the limit of detection is 0.5 ng/mL. We believe this UCL system possesses a promising potential in the monitoring and early diagnosis of infections.
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