期刊
HYPERTENSION RESEARCH
卷 44, 期 12, 页码 1606-1616出版社
SPRINGERNATURE
DOI: 10.1038/s41440-021-00734-x
关键词
Blood pressure; Diabetes; Primary prevention; Statin
Intensive lipid-lowering therapy is recommended for type 2 diabetes mellitus (T2DM) patients with microvascular complications, especially for those with hypertension, to reduce cardiovascular disease risk. Among T2DM patients with retinopathy and BP >= 130/80 mmHg, intensive statin therapy targeting LDL-C < 70 mg/dL was associated with lower CVD risk compared to standard therapy.
Intensive lipid-lowering therapy is recommended in individuals exhibiting type 2 diabetes mellitus (T2DM) with microvascular complications (as high-risk patients), even without known cardiovascular disease (CVD). However, evidence is insufficient to stratify the patients who would benefit from intensive therapy among them. Hypertension is a major risk factor, and uncontrolled blood pressure (BP) is associated with increased CVD risk. We evaluated the efficacy of intensive vs. standard statin therapy for primary CVD prevention among T2DM patients with retinopathy stratified by BP levels. We used the dataset from the EMPATHY study, which compared intensive statin therapy targeting low-density lipoprotein cholesterol (LDL-C) levels of <70 mg/dL and standard therapy targeting LDL-C levels ranging from >= 100 to <120 mg/dL in T2DM patients with retinopathy without known CVD. A total of 4980 patients were divided into BP >= 130/80 mmHg (systolic BP >= 130 mmHg and/or diastolic BP >= 80 mmHg, n = 3335) and BP < 130/80 mmHg (n = 1645) subgroups by baseline BP levels. During the median follow-up of 36.8 months, 281 CVD events were observed. Consistent with previous studies, CVD events occurred more frequently in the BP >= 130/80 mmHg subgroup than in the BP < 130/80 mmHg subgroup (P < 0.001). In the BP >= 130/80 mmHg subgroup, intensive statin therapy was associated with lower CVD risk (HR 0.70, P = 0.015) than standard therapy after adjustment. No such association was observed in the BP < 130/80 mmHg subgroup. The interaction between BP subgroup and statin therapy was significant. In conclusion, intensive statin therapy targeting LDL-C < 70 mg/dL provided benefits in primary CVD prevention when compared with standard therapy among T2DM patients with retinopathy and BP >= 130/80 mmHg.
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