期刊
HYPERTENSION IN PREGNANCY
卷 40, 期 3, 页码 218-225出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10641955.2021.1958836
关键词
Gene polymorphism; il-32; preeclampsia; pregnancy
资金
- Shahid Sadoughi University of Medical Sciences
The study revealed an association between IL-32 gene polymorphism and serum levels of IL-32 with susceptibility to preeclampsia (PE). Higher frequencies of CT, TT genotypes, and T allele for rs4786370 were found in PE patients, along with a significant increase in serum IL-32 level.
Objective: To determine association between IL-32 gene polymorphism, and serum levels of IL-32 and susceptibility to preeclampsia (PE). Methods: The frequency of IL-32 rs9927163 and rs4786370 polymorphisms was determined by PCR-RFLP. Also ELISA was used to determine the levels of serum IL-32. Results: Regarding rs4786370 C/T SNPs, the frequencies of CT, TT genotypes, and T allele were shown to be higher in the PE patients. IL-32 serum level significantly increased in the PE patients. Conclusion: Variety of allele and genotype IL32 rs4786370 as well as a rise in serum level of IL-32 can be regarded as a risk factor for PE.
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